Preventive interventions for individuals at ultra high risk for psychosis: An updated and extended meta-analysis

C Mei; M van der Gaag; B Nelson; F Smit; HP Yuen; M Berger; M Krcmar; P French; GP Amminger; A Bechdolf; P Cuijpers; AR Yung; PD McGorry

Journal article

Preventive interventions for individuals at ultra high risk for psychosis: An updated and extended meta-analysis

C Mei, M van der Gaag, B Nelson, F Smit, HP Yuen, M Berger, M Krcmar, P French, GP Amminger, A Bechdolf, P Cuijpers, AR Yung, PD McGorry

Clinical Psychology Review | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

DOI: 10.1016/j.cpr.2021.102005

Abstract

Intervention at the earliest illness stage, in ultra or clinical high-risk individuals, or indicated prevention, currently represents the most promising strategy to ameliorate, delay or prevent psychosis. We review the current state of evidence and conduct a broad-spectrum meta-analysis of various outcomes: transition to psychosis, attenuated positive and negative psychotic symptoms, mania, depression, anxiety, general psychopathology, symptom-related distress, functioning, quality of life, and treatment acceptability. 26 randomized controlled trials were included. Meta-analytically pooled interventions reduced transition rate (risk ratio [RR] = 0.57, 95%CI 0.41–0.81) and attenuated positive..

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University of Melbourne Researchers

Cristina Mei Author

Barnaby Nelson Author

Hok Yuen Author

Maximus Berger Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

PDM is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1155508). BN is supported by an NHMRC Senior Research Fellowship (1137687). The funding source had no role in the study design, data collection, analysis and interpretation, writing of the manuscript, and in the decision to submit the article for publication.